Current Position, Affiliation
- Professor, Division of Nephrology, Teikyo University School of Medicine, Japan
Awards & Honors
- 2024, Paul Dudley White International Scholar Award, The American Heart Association
- 2019, American Journal of Hypertension John Laragh Research Award
Selected Publications
- Fujii W, Yamazaki O, Hirohama D, Kaseda K, Kuribayashi-Okuma E, Tsuji M, Hosoyamada M, Kochi Y, Shibata S. Gene-environment interaction modifies the association between hyperinsulinemia and serum urate levels through SLC22A12. J Clin Invest. 2025 Mar 18;135(10):e186633.
- Hayama Y, Kuribayashi-Okuma E, Fujii N, Ochiai-Homma F, Yamazaki O, Tsurutani Y, Nishikawa T, Shibata S. ENaCγ in Urinary Extracellular Vesicles as an Indicator of MR Signaling in Primary Aldosteronism. Hypertension. 2024 Dec;81(12):2457-2467
- Ishizawa K, Wang Q, Li J, Xu N, Nemoto Y, Morimoto C, Fujii W, Tamura Y, Fujigaki Y, Tsukamoto K, Fujita T, Uchida S, Shibata S. Inhibition of Sodium Glucose Cotransporter 2 Attenuates the Dysregulation of Kelch-Like 3 and NaCl Cotransporter in Obese Diabetic Mice. J Am Soc Nephrol. 2019 May;30(5):782-794.
- Ishizawa K, Wang Q, Li J, Yamazaki O, Tamura Y, Fujigaki Y, Uchida S, Lifton RP, Shibata S. Calcineurin dephosphorylates Kelch-like 3, reversing phosphorylation by angiotensin II and regulating renal electrolyte handling. Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3155-3160.
- Shibata S, Rinehart J, Zhang J, Moeckel G, Castañeda-Bueno M, Stiegler AL, Boggon TJ, Gamba G, Lifton RP. Mineralocorticoid receptor phosphorylation regulates ligand binding and renal response to volume depletion and hyperkalemia. Cell Metab. 2013 Nov 5;18(5):660-71.
Novel Regulation and Function in Renal Na⁺ Associated Transporters
Role
Speaker
Date & Time
12/07 11:25 - 11:40
Place
Room 2 ( 701B )
Lecture Title
Role of Ubiquitin Ligase Kelch-like 3 in Health and Diseases