Richard Smith

Professor, University of Iowa

Current Position, Affiliation

Sterba Research Professor, Carver College of Medicine, University of Iowa, Iowa City, IA, USA
Director, Molecular Otolaryngology and Renal Research Laboratories, Carver College of Medicine, University of Iowa, Iowa City, IA, USA
Director, Iowa Institute of Human Genetics, Carver College of Medicine, University of Iowa, Iowa City, IA, USA

Education / Training

1977, M.D., Baylor College of Medicine, Houston, TX, USA

Professional and Research Experience

1977 - 1982, Resident, Department of Otolaryngology, Baylor College of Medicine, Houston, TX, USA

Awards & Honors

2006, The National Academy of Medicine
2009, The Association of American Physicians
2013, Albert C. Muse Prize
2014, Flexner Distinguished Lecturer
2025, Shambaugh Prize

Selected Publications

Smith RJH, Appel GB, Blom AM, Cook HT, D'Agati VD, Fakhouri F, Fremeaux-Bacchi V, Józsi M, Kavanagh D, Lambris JD, Noris M, Pickering MC, Remuzzi G, de Córdoba SR, Sethi S, Van der Vlag J, Zipfel PF, Nester CM. C3 glomerulopathy - understanding a rare complement-driven renal disease. Nat Rev Nephrol. 2019 Mar;15(3):129-143. doi: 10.1038/s41581-018-0107-2. PMID: 30692664; PMCID: PMC6876298
Zhang Y, Keenan A, Dai DF, May KS, Anderson EE, Lindorfer MA, Henrich JB, Pitcher GR, Taylor RP, Smith RJH. C3(H2O) prevents rescue of complement-mediated C3 glomerulopathy in Cfh-/- Cfd-/- mice. JCI Insight. 2020 May 7;5(9):e135758. doi: 10.1172/jci.insight.135758. PMID: 32376801. PMCID: PMC7253029
Zhang Y, Martin B, Spies MA, Roberts SM, Nott J, Goodfellow RX, Nelson AFM, Blain SJ, Redondo E, Nester CM, Smith RJH. Renin and renin blockade have no role in complement activity. Kidney Int. 2024 Feb;105(2):328-337. doi: 10.1016/j.kint.2023.11.005. Epub 2023 Nov 25. PMID: 38008161
Vivarelli M, Barratt J, Beck LH Jr, Fakhouri F, Gale DP, Goicoechea de Jorge E, Mosca M, Noris M, Pickering MC, Susztak K, Thurman JM, Cheung M, King JM, Jadoul M, Winkelmayer WC, Smith RJH; for Conference Participants. The role of complement in kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int. 2024 Sep;106(3):369-391. doi: 10.1016/j.kint.2024.05.015. Epub 2024 Jun 4. PMID: 38844295
Kavanagh D, Bomback AS, Vivarelli M, Nester CM, Remuzzi G, Zhao MH, Wong EKS, Wang Y, Krishnan I, Schuhmann I, Trapani AJ, Webb NJA, Meier M, Israni RK, Smith RJH; APPEAR-C3G investigators. Oral iptacopan therapy in patients with C3 glomerulopathy: a randomised, double-blind, parallel group, multicentre, placebo-controlled, phase 3 study. Lancet. 2025 Sep 25:S0140-6736(25)01148-1. doi: 10.1016/S0140-6736(25)01148-1. Epub ahead of print. PMID: 41016405

APSN-KDIGO Joint Symposium: State-of-the-Art 2025 Management of C3G: Evolution in Diagnosis, Evaluation, and Treatments

Role

Speaker

Date & Time

12/06 15:25 - 15:45

Place

Room 4 ( 701EF )

Lecture Title

Management of C3 Glomerulopathy in 2025: Optimal Diagnosis and Workup